The dose may be adjusted depending on clinical response and tolerability of the individual patient, within the range of 300 to 800 mg/day administered twice daily. In individual patients, in the event of tolerance concerns, clinical trials have indicated that dose reduction to a minimum of 200 mg could be considered.įor preventing recurrence in bipolar disorderįor preventing recurrence of manic, mixed or depressive episodes in bipolar disorder, patients who have responded to quetiapine for acute treatment of bipolar disorder should continue therapy at the same dose. Doses greater than 300 mg should be initiated by physicians experienced in treating bipolar disorder. Individual patients may benefit from a 600 mg dose. In clinical trials, no additional benefit was seen in the 600 mg group compared to the 300 mg group (see section 5.1). The total daily dose for the first four days of therapy is 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3) and 300 mg (Day 4). Seroquel should be administered once daily at bedtime. The usual effective dose is in the range of 400 to 800 mg/day.įor the treatment of major depressive episodes in bipolar disorder The dose may be adjusted depending on clinical response and tolerability of the individual patient, within the range of 200 to 800 mg/day. Further dosage adjustments up to 800 mg/day by Day 6 should be in increments of no greater than 200 mg/day. The total daily dose for the first four days of therapy is 100 mg (Day 1), 200 mg (Day 2), 300 mg (Day 3) and 400 mg (Day 4). Depending on the clinical response and tolerability of the individual patient, the dose may be adjusted within the range 150 to 750 mg/day.įor the treatment of moderate to severe manic episodes in bipolar disorderįor the treatment of manic episodes associated with bipolar disorder, Seroquel should be administered twice a day. The total daily dose for the first four days of therapy is 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3) and 300 mg (Day 4) From Day 4 onwards, the dose should be titrated to the usual effective dose of 300 to 450 mg/day. Seroquel can be administered with or without food.įor the treatment of schizophrenia, Seroquel should be administered twice a day. It must therefore be ensured that patients receive clear information on the appropriate dosage for their condition. Date of first authorisation/renewal of the authorisationĭifferent dosing schedules exist for each indication. 6.6 Special precautions for disposal and other handling.4.7 Effects on ability to drive and use machines.4.5 Interaction with other medicinal products and other forms of interaction.4.4 Special warnings and precautions for use.4.2 Posology and method of administration.Show table of contents Hide table of contents
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